Angiotensinogen Gene Haplotype and Hypertension

Angiotensinogen gene haplotype and hypertension: interaction with ACE gene I allele.

There are many reports demonstrating the association of renin-angiotensin system gene polymorphisms with hypertension in different populations. In the present study, we used haplotype analyses of the angiotensinogen gene with a new permutation-based hypothesis testing method to determine the association between multilocus angiotensinogen gene polymorphisms and hypertension in a relatively homog...

Angiotensinogen Gene Polymorphisms and Hypertension

Angiotensinogen gene and hypertension in Chinese.

The renin-angiotensin system plays a major role in regulating blood pressure and maintaining electrolyte and volume homeostasis. Previously, the angiotensinogen gene, which encodes the key substrate for renin within this system, has been reported linked to and associated with essential hypertension in White Europeans, African-Caribbeans, and Japanese. Therefore, we investigated whether the angi...

Differential Angiotensinogen Haplotype Regulation in Angiotensinogen-Expressing Cells

A number of naturally occurring polymorphisms exist in the human angiotensinogen locus, some of which have been associated with essential hypertension, preeclampsia, and other medical disorders. However, to date there has been no comprehensive determination of the significance of specific haplotypes in relation to the regulation of angiotensinogen expression. We cloned the promoters extending f...

TRANSLATIONAL PHYSIOLOGY Three single-nucleotide polymorphisms of the angiotensinogen gene and susceptibility to hypertension: single locus genotype vs. haplotype analysis

Shyh-Jong Wu, Fu-Tien Chiang, Wei J. Chen, Pi-Hua Liu, Kwan-Lih Hsu, Juey-Jen Hwang, Ling-Ping Lai, Jiunn-Lee Lin, Chuen-Den Tseng, and Yung-Zu Tseng Graduate Institute of Physiology, National Taiwan University College of Medicine, and Department of Internal Medicine, National Taiwan University Hospital, and Institute of Epidemiology, National Taiwan University College of Public Health, Taipei ...